Case Report

Verruca Vulgaris on The Soft Palate: A Case Report with Immunohistochemical Evaluation

  • Esra Gürlek OLGUN
  • Bülent Ferdi ÖZEL

Meandros Med Dent J 2007;8(1):43-45

Verrucae vulgares (VV) have been described in the oral cavity. ButVVon the soft palatal mucosa are very rare. It has been suggested that the diagnosis of oral verruca should be confined to those lesions which show clinical and histological criteria similar to those found in VV of the skin. Human papillomavirus (HPV) antigen has been detected in 55-75%of oralVVcases.HPV2,-4 and -57 were isolated from oralVV. The oral lesions of skin-related HPV types are localized predominantly to the lip, palate, buccal mucosa, tongue and gingiva with decreasing frequency; in contrast those of mucosal HPV types are located in the palate, lip, tongue, buccal mucosa and gingiva.Abiopsy specimen of an papillomatous lesion on the soft palate was taken from a 62-year-oldwoman.The sections showed papillary growth of the epitheliumwith hyperkeratosis, parakeratosis and koilocytotic changes of the cells located in the upper layers of the oral squamous cell epithelium. Sections were stained with the immunoperoxidase-PAP method (Dako-PAP, USA) to demonstrate the genus-specific papillomavirus antigen. Our case demonstrated the presence of the group-specific antigen in the superficial parakeratinized and granular cells.These histological ve clinical features correspondedwell to those ofVVon the skin.

Keywords: Verruca, vulgaris, soft palate