Clinical Investigation

The Antibiotic Resistance of Staphylococci Isolated of Clinical Specimens

  • Neriman AYDIN
  • Berna GÜLTEKIN
  • Mete EYIGÖR
  • Mustafa GÜREL

Received Date: 22.10.2001 Accepted Date: 29.12.2001 Meandros Med Dent J 2001;2(3):21-26

Objective: The aim of this study was to detect the antibiotic resistance of staphylococci strains which were isolatedfromvarious clinical specimens. Methods: This study included 274 Staphylococcus aureus (S. aureus) and 172 coagulase negative staphylococci strains which were identified with classical methods. Antibiotic resistance of strains to penicilline, methicillin, erythromycin, clindamycin, co-trimoxazole, ciprofloxacin, vancomycin and fucidic acid were investigated by Kirby-Bauer disc diffusionmethod, while in the detectionofmethicilline resistance oxacilline discs were used. Results: Amongthe274 S. aureus strains, 92.3% werefoundresistantto penicilline, 10.9% to methicillin, 21.5% to erythromycin 14.8% to clindamycin, 15.8% to co-trimoxazole, 7.3% to ciprofloxacin, 5.7% to fucidic acid. Among 172 CNS strains 84.2% were found resistant to penicilline, 38.8% to methicillin, 54.8% to erythromycin, 44.4% to clindamycin, 42.2% to co-trimoxazole, 25% to ciprofloxacin and 28.1% to fucidic acid. Vancomycin resistance was not detected Conclusion: In this study we found that strains of coagulase negative staphylococci were much more resistant than S. aureus to antibiotics and all staphylococci were susceptible to vancomycin.

Keywords: Staphylococus aureus, coagulase negative staphylococci, methicillin resistance, antibiotic resistance