Clinical Investigation

Squamous Differentiation In Transitional Bladder Carcinomas And Its Correlation With Grade, Stage, DNA Content, And Prognosis

  • Füruzan KACAR
  • Elif SELEK
  • Cem YENIYOL
  • Sedat ÇIÇEK

Received Date: 15.12.2000 Accepted Date: 17.04.2001 Meandros Med Dent J 2001;2(1):17-20

Aims: In this study, the correlation of squamous differentiation with tumor grade, stage, DNA content and prognosis was investigated in tansitional cell carcinomas. Materials and Methods: Cases of transitional cell carcinomas with squamous differentiation were histologically graded, (Mostofi), clinically staged (AJCC), and DNA content of tumor cells were determined with flow cytometry. These data were correlated with prognosis using Pearson chi square, Pearson correlation analysis and Kaplan-Meier analysis. Results: Only 2 of 16 cases of grade I transitional cell carcinoma showed squamous differentiation. Among grade III cases 8 of 14 showed squamous differentiation, while 6 cases didn't. Only 3 of 17 stage I cases showed squamous differentiation; 14 cases didn't. Five of 11 stage II cases showed squamous differentiation; 6 cases didn't. Two out of 2 cases of stage III transitionel cell carcinoma showed squamous differentiation. Out of 15 cases which had diploid DNA content, only 1 showed squamous differentiation while 14 didn't. Among 15 cases with aneuploid DNA content, 9 had squamous differentiation; 6 cases didn't. During the 4 years follow up period, only 1 of 20 cases of transitional cell carcinoma without squamous differentiation were fatal, while three of 10 cases with squamous differentiation were fatal. Conclusion: While no direct correlation between squamous differentiation and survival could be demonstrated, since there was a significant relation between squamous differentiation and stage (p

Keywords: Squamous differentiation, bladder carcinoma, flowcytometry