Evaluation of Internal Dosimetry Methods in Nuclear Medicine Applications

  • Yasemin Parlak
  • Mustafa Demir

Meandros Med Dent J 2013;14(3):47-54

Many radionuclides are used for diagnostic and therapeutic in nuclear medicine applications. The knowledge of radiation dose absorbed by different organs in the body is critical to evaluate known risks and benefits of these applications. Internal dosimetry deals with the determination of the amount and the spatial and temporal distribution of radiation energy deposited in tissue by radionuclides within the body. Widely used in nuclear medicine in the treatment of thyroid cancer and hyperthyroidism radioisotope I-131, as well as routine practice in recent years into the treatment of hepatocellular carcinoma and neuroendocrine tumor Lu-177 and Y-90 also successfully applied to radioisotopes. In terms of risk assessment, the organ dose calculations Medical Internal Radiation Dosimetry (MIRD), as well as the application of the standard set by the patient-specific parameters in the evaluation of kinetics and anatomy is important. The methods used internal dosimetry calculations in this study are considered and the appropriate models representing individuals of different ages and regardless of gender are described with mathematical formulations.

Keywords: Internal dosimetry, MIRD method, radiation dose