Clinical Investigation

Does sepragel (hylan b) Have any Preventive Effect on Two-Stage Orchidopexy in the First Stage?

  • Mesut YAZICI
  • Mustafa Onur ÖZTAN
  • Barlas ETENSEL
  • Mustafa Harun GÜRSOY

Received Date: 04.05.2006 Accepted Date: 11.07.2006 Meandros Med Dent J 2006;7(1):11-14

Objective: In two stage orchidopexy, it is a known fact that the testis which could not be fixed in the scrotum during the first operation adheres to circumferential tissue. The aim of this study was to evaluate the effect of Sepragel, an adhesion barrier agent, on fibrosis and spermatogenesis in two-stage undescending testis in a rat model. Methods: Six adult male rats were operated. Left and right testes of rats were taken out simultaneously via inguinal incision and placed back in the inguinal canal. Afterwards, 0.5 cc Sepragel was applicated in the surrounding tissue of the right testes (Spragel group). Left testes served as controls. All testes were extracted in the postoperative 21st day and they were examined histopathologically and their scores of fibrosis and inflammation and Johnsen scores were assessed. Mann-Whitney U and ki-square tests used for statistical analysis. Results: There was no significant difference between Sepragel and control groups in terms of fibrosis, inflammation and Johnsen scores. Conclusion: The use of Sepragel did not have any effect on the degree of fibrotic adhesions and spermatogenesis in a rat model of two-stage orchidopexy.

Keywords: adhesion barrier, testis, Sepragel, orchidopexy