Original Article

A Model Of Short Bowel Syndrome Independent of Total Parenteral Nutrition (Experimental Study in Rats)

  • Gülnur Göllü
  • Mine Senyücel
  • Aydin Yagmurlu

Received Date: 03.10.2013 Accepted Date: 09.10.2013 Meandros Med Dent J 2013;14(3):21-25

OBJECTIVE: Short bowel syndrome (SBS) which causes significant morbidity and mortality in children includes short bowel transit time, inadequate digestion and absorption as a result of intensive intestine resections. Most of the complications in SBS ocur as a result of total parenteral nutrition (TPN). However there are some other complications independent of TPN, the aim is to compose a SBS model which is independent of TPN. MATERIAL and METHODS: Two groups of 37 male Wister Albino rats which have weights of 180-220 g were generated. Sham group contained 16 and SBS group contained 21 rats. In sham group, ileum was transected 15cm proximal to ileocecal valve and end-to-end anastomosis was performed without resection. In SBS group, small intestines between 5cm distal to Treitz ligament and 10cm proximal to ileocecal valve were resected after isolating mesenteric vessels, then end-to-end anastomosis was performed between jejunum and ileum. The rats were fed equally and their weight were followed daily for seven weeks. RESULTS: The rats in SBS group have statistically significant weight loss hence first week when compared to those in sham group. Although they had weight gain in time they couldn't catch up with those in sham group however they continued to survive (*p CONCLUSION: The rats survived in this TPN independent experimental model and it provides evaluation of SBS physiopathology such as liver failure without the effects of TPN.

Keywords: Short bowel syndrome, total parenteral nutrition, small intestine