Case Report

Subgroup Incompatibility Due to Anti-E In Newborn: Two Case Reports

10.5152/adutfd.2014.141629

  • Özmert Muhammet Ali Özdemir
  • Kazım Küçüktaşçı
  • Özlem Şahin
  • Çiğdem Eliaçık
  • Hacer Ergin

Received Date: 18.01.2013 Accepted Date: 05.11.2013 Meandros Med Dent J 2014;15(2):77-78

Hemolytic disease of newborn is a severe disease, resulting from maternal red blood cell (RBC) alloantibodies directed against fetal RBCs. This is mostly due to Rh (D), ABO incompatibility and also rarely due to subgroup incompatibility. Mild hyperbilirubinemia to severe hemolytic reactions requiring exchange transfusion therapy can occur in subgroup incompatibility. In this article, we report two patients who developed hemolytic disease of the newborn due to anti-E. Case 1 was treated with intensive phototherapy and IVIG immediately after birth. This case was readmitted to the hospital at 33rd day of life because of jaundice and severe anemia and treated with IVIG, phototherapy and erythrocyte transfusion. Case 2 was referred to our hospital at postnatal second day because of total bilirubin levels of 21 mg/dL. This case was also treated with IVIG, intensive phototherapy and no any complications of hemolysis developed during clinical follow up.

Keywords: Subgroup incompatibility, newborn, jaundice