Case Report

Intravenous Immunglobulin Therapy In A CaseWith Chronic Bullous Disease of Childhood

  • Pamir GÜLEZ
  • Murat HIZARCIOĞLU
  • Ertan KAYSERİLİ
  • Şule AFSAR
  • Ragip ORTAÇ
  • Hursit APA

Received Date: 14.10.2008 Accepted Date: 19.12.2008 Meandros Med Dent J 2009;10(2):33-35

Chronic bullous disease of childhood, one of the subepidermal bullous diseases is uncommon, and its etiology has not fully understood. A linear deposition of IgA at the epidermal basement membrane on direct immunoflorescence is pathognomonic for the disease. Dapson is commonly used in the therapy. Intravenous immunglobulin is a recent choice in the treatment. A twelve-months old boy was admitted to the hospital with the complaints of mutipl blisters on his face, especially perioral region, buttocks and extremities. Examination of the skin biopsy specimen with direct immunoflorescence method showed linear deposits of IgA along the dermoepidermal junction. In the light of the findings, condition was diagnosed as chronic bullous disease of childhood. Following the intravenous immunglobulin use for treatment, the skin lesions revealed rapid healing within three days.

Keywords: Chronic bullous disease of childhood, immunglobulinA, intravenous immunglobulin