Clinical Investigation

Lipid Peroxidation In Patients With Multipl Myeloma

  • Zahit BOLAMAN
  • Süleyman DEMIR
  • Mehmet H. KÖSEOGLU
  • Yasar ENLI
  • Gürhan KADIKÖYLÜ
  • Diler ASLAN

Received Date: 06.04.2000 Accepted Date: 12.12.2000 Meandros Med Dent J 2000;1(3):13-15

Aim of study: We investigated the malondialdehyde (MDA) levels as a parameter of lipid peroxidation in patients with multiple myeloma as a preliminary report. Material and method: Fasting venous blood samples were drawn in 12 patients with multiple myeloma and 15 healthy persons. Serum was separated and frozen at -20 C°. All samples were thawed at room temperature and MDA levels were measured by the method in which MDA reacted with thiobarbituric acid and produced a colored complex. This colored complex was read by optic scale at 532 wavelength. Results: MDA levels were 1.51±0.16nmol/ml in patients withmultiple myeloma and 0.97±0.11 nmol/mlinthe control group (P0.05). Conclusion: Plasma MDA levels were found to be higher in multiple myeloma in comparison to control group (p

Keywords: Multiple myeloma, malondialdehyde, oxidative stress