Endoplasmic Reticulum Stress and Pancreatic Cancer


  • Kemal Ergin
  • Esra Gökmen

Received Date: 07.08.2014 Accepted Date: 28.08.2014 Meandros Med Dent J 2015;16(1):20-24

Endoplasmic reticulum (ER) stress, which results from different stimuli, is an important cellular event. There are different types of response to ER stress. One of them is evolutionarily conserved unfolded protein response (UPR). UPR has three sensors for further activation of molecules. These sensors are inositol-requiring enzyme 1 (IRE1), activated transcription factor 6 (ATF6), and ER-resident protein kinase RNA (PKR)-like ER kinase (PERK). In the absence of ER stress, these sensors are maintained in an inactive state. However, under ER stress conditions, they became activated and induce the downstream targets. As a consequence of ER stress, the cell may stay alive or became dead. Several studies have shown that ER stress is associated with different types of diseases such as diabetes mellitus, Alzheimer’s disease, prion disease, and cancer. As a cancer type, it has been shown that pancreatic cancer is also associated with ER stress. Pancreatic cancer has a low cure potential with its late diagnosis. Its association with ER stress is seen as a new therapeutic approach. The aim of this is review is to provide an overview of the mechanisms of ER stress and its relationship with pancreatic cancer, one of the diseases in which ER stress affects pathogenesis.

Keywords: Endoplasmic reticulum, pancreatic cancer, stress